The Arthus reaction in guinea-pig knee joints. A test for anti-inflammatory drugs
Identifieur interne : 003A30 ( Main/Exploration ); précédent : 003A29; suivant : 003A31The Arthus reaction in guinea-pig knee joints. A test for anti-inflammatory drugs
Auteurs : Alan Blackham [Royaume-Uni] ; Henryk Radziwonik [Royaume-Uni] ; Ian H. Shaw [Royaume-Uni]Source :
- Agents and Actions [ 0065-4299 ] ; 1975-12-01.
English descriptors
- Teeft :
- Antiinflammatory agents, Arthus, Arthus reaction, Arthus reactions, Blood cells, Carrageenin foot oedema, Cell counts, Cell infiltration, Chloroquine diphosphate, Cohn fraction, Complement depletion, Complement titrations, Control animals, Control hahgg, Cyproheptadine, Dos, Dose levels, Exudate volume, French laboratories, Geigy pharmaceuticals, Gold triethyl phosphine, Heat aggregated, Human gamma globulin, Igg1, Igg1 antibody, Igg2, Igg2 antibody, Immune complexes, Important role, Indomethacin, Intraarticular injection, Intravenous, Intravenous injection, Joint macroscopy, Joint size, Knee joints, Leucocyte, Leucocyte counts, Leucocyte infiltration, Macroscopy, Macroscopy scores, Mustine, Mustine hydrochloride, Open columns, Oral administration, Ovalbumin, Passive arthus reaction, Periarticular tissues, Phenylbutazone, Phosphate buffer, Polymorphonuclear, Polymorphonuclear leucocyte depletion, Polymorphonuclear leucocytes, Prednisolone, Prednisolone sodium phosphate, Prostaglandin, Prostaglandin synthetase inhibitors, Protein fraction, Rheumatoid arthritis, Serum complement levels, Significant reduction, Single experiment, Smith kline, Sudoxicam, Synovial, Synovial fluid, Synovial fluid leucocyte counts, Syntex pharmaceuticals, Total leucocyte counts, Trasylol, Unfractionated antiserum, Various doses, Ward blenkinsop, White blood cell counts.
Abstract
Abstract: A reversed passive Arthus reaction was produced in guinea-pig knee joints by intravenous injection of ovalbumin and intra-articular injection of homologous anti-ovalbumin antiserum or specific IgG2 antibody. The optimum response was obtained by varying the concentration of antigen while keeping the amount of antibody constant. Joint swelling, leucocyte infiltration in the synovial fluid and joint pathology were measured 4–6 hours and 24 hours after initiation of the reaction. The PRA lesions were almost completely inhibited by complement or polymorphonuclear leucocyte depletion. The effects of a range of drugs on the 4–6 hours response were investigated following intraperitoneal or oral administration. Cyproheptadine hydrochloride, Trasylol, indomethacin, aspirin, phenylbutazone, prednisolone sodium phosphate, chloroquine diphosphate, SKF36914 (gold triethyl phosphine), cyclophosphamide, ketoprofen, sudoxicam and naproxen all reduced one or more of the symptoms of inflammation. However, cyproheptadine was only active at high and probably non-specific dose levels. D(−)penicillamine hydrochloride and mepyramine maleate were inactive.
Url:
DOI: 10.1007/BF01972689
Affiliations:
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A test for anti-inflammatory drugs</title><author><name sortKey="Blackham, Alan" sort="Blackham, Alan" uniqKey="Blackham A" first="Alan" last="Blackham">Alan Blackham</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Department of Pharmacology and Biochemistry, R. & D. Laboratories, Fisons Ltd., Loughborough, Leicester</wicri:cityArea></affiliation></author><author><name sortKey="Radziwonik, Henryk" sort="Radziwonik, Henryk" uniqKey="Radziwonik H" first="Henryk" last="Radziwonik">Henryk Radziwonik</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Department of Pharmacology and Biochemistry, R. & D. Laboratories, Fisons Ltd., Loughborough, Leicester</wicri:cityArea></affiliation></author><author><name sortKey="Shaw, Ian H" sort="Shaw, Ian H" uniqKey="Shaw I" first="Ian H." last="Shaw">Ian H. Shaw</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Department of Pharmacology and Biochemistry, R. & D. 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The optimum response was obtained by varying the concentration of antigen while keeping the amount of antibody constant. Joint swelling, leucocyte infiltration in the synovial fluid and joint pathology were measured 4–6 hours and 24 hours after initiation of the reaction. The PRA lesions were almost completely inhibited by complement or polymorphonuclear leucocyte depletion. The effects of a range of drugs on the 4–6 hours response were investigated following intraperitoneal or oral administration. Cyproheptadine hydrochloride, Trasylol, indomethacin, aspirin, phenylbutazone, prednisolone sodium phosphate, chloroquine diphosphate, SKF36914 (gold triethyl phosphine), cyclophosphamide, ketoprofen, sudoxicam and naproxen all reduced one or more of the symptoms of inflammation. However, cyproheptadine was only active at high and probably non-specific dose levels. D(−)penicillamine hydrochloride and mepyramine maleate were inactive.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li></region></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Blackham, Alan" sort="Blackham, Alan" uniqKey="Blackham A" first="Alan" last="Blackham">Alan Blackham</name></region><name sortKey="Radziwonik, Henryk" sort="Radziwonik, Henryk" uniqKey="Radziwonik H" first="Henryk" last="Radziwonik">Henryk Radziwonik</name><name sortKey="Shaw, Ian H" sort="Shaw, Ian H" uniqKey="Shaw I" first="Ian H." last="Shaw">Ian H. Shaw</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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